Patients with Post-Essential Thrombocythemia and Post-Polycythemia Vera Differ from Patients With Primary Myelofibrosis

The most common causes of morbidity and mortality in patients with myeloproliferative neoplasms (MPNs) are thrombotic and hemorrhagic complications. The JAK2V617F mutation, commonly found in MPNs, correlates with several clinical and laboratory characteristics even if the relevance of JAK2V617F allele burden in the natural history of these diseases is unclear. The researchers in this study suggest that patients with MPNs with JAK2V617F allele burden higher than 75% should be considered high-risk patients, being prone to develop thrombo-hemorrhagic complications during the course of the disease.

Ann Hematol