Progenitor Genotyping Reveals a Complex Clonal Architecture in a Subset of CALR-Mutated Myeloproliferative Neoplasms

Collectively, the studies discussed demonstrate that occasional patients with CALR mutation-positive essential thrombocythemia or myelofibrosis carry other myeloproliferative neoplasms-initiating genetic mutations (including JAK2 V617F), acquire "secondary mutations" before or after the CALR mutation, or evolve over time to being CALR mutation-homozygous.

Br J Haematol