Homozygous JAK2 Germline Haplotype May Be Linked to Worse Survival in Myelofibrosis

A recent study demonstrated an association between nullizygosity (i.e., two loss-of-function mutations in JAK2) for the JAK2 46/1 haplotype and worse overall survival in an expanded population of patients with primary myelofibrosis (hazard ratio [HR] 1.5; 95% CI, 1.1-1.9), particularly in patients with a JAK2 driver mutation (p < .001).

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