Downregulation of GATA1 Drives Impaired Hematopoiesis in Primary Myelofibrosis

In a recent study on primary myelofibrosis, investigators noted that reduced GATA1 expression and impaired differentiation were limited to megakaryocytes, consistent with a pro-proliferative effect of a GATA1 deficiency on this lineage. Importantly, they found that expression of GATA1 effectively rescued maturation of primary myelofibrosis megakaryocytes. Together, these results suggest that ribosomal deficiency contributes to impaired megakaryopoiesis in myeloproliferative neoplasms.

J Clin Invest