A New Therapeutic Target for Myelofibrosis is Cause for Gli

In a new study, researchers report that Gli1+ mesenchymal stromal cells play a central role in bone marrow fibrosis development and represent a new therapeutic target. After first confirming that murine and human BM Gli1+ cells are of MSC-origin, genetic fate-tracing in two murine PMF models showed that Gli1+ cells are mobilized from perivascular and endosteal niches by the malignant hematopoietic clone to become myofibroblasts.

Sci Transl Med